Abstract— The Internet of Things (IoT) nodes and applications have been expanding rapidly; thereby driving the increasing need for ultra-low power RF front-end circuit design, particularly for battery-powered applications.  This work presents a highly efficient ultra-low power low-noise amplifier (LNA) circuit designed particularly for IoT tire pressure monitoring system (TPMS) applications. With an inductive degenerated cascode topology, the proposed LNA achieves low noise figure, high gain, and highly efficient power consumption. As determined through comprehensive simulations conducted using the TSMC CMOS 0.18 μm technology, the LNA’s superior performance exhibits a noise figure as low as 2.7 dB, high gain of 20.52 dB, and low power consumption of 0.1 mW in the most efficient state. Thus, LNA can possibly enhance TPMS sensitivity and reliability substantially, representing an advancement in IoT technology adaptability across varying applications.