Abstract— Wireless digital communication networks are rapidly expanding resulting in a demand for reliable and high spectral efficiency systems. Multi-Carrier Code Division Multiple Access (MC-CDMA) has emerged recently as a promising candidate for the next generation broad-band mobile networks. It was found that Radon based orthogonal frequency division multiplexing (OFDM) and discrete Slantlet transform (SLT) based OFDM are capable of reducing inter symbol interference (ISI) and inter carrier interference (ICI), which are caused by the loss of orthogonality between the carriers. Radon-based OFDM and SLT-based OFDM can also support much higher spectrum efficiency than fast Fourier transform-based OFDM (FFT-OFDM). In this paper, a novel Radon-SLT- MC-CDMA transceiver design will be presented based on a new design of a Radon-SLT-OFDM that is used as a basic building block in the design of MC-CDMA transceiver to increase orthogonality against the multi-path frequency selective fading channels. Simulation results are provided to demonstrate the significant gains in performance due to the proposed technique. The bit error rate (BER) performance of the proposed Radon-SLT- MC-CDMA scheme was compared with that of FFT based MC-CDMA, Radon based MC-CDMA, and discrete Multiwavelet transform (DMWT) based MC-CDMA and tested in additive white Gaussian noise (AWGN), Flat fading and Selective fading channels. The simulation results showed that the proposed system outperforms the other three systems.